Thinner Retinas Tied To Higher Atrial Fibrillation Risk, Large Study Finds
People whose retinas showed thinning in a specific layer of nerve tissue faced a 27% higher risk of developing atrial fibrillation years later for every added step of thinning measured, according to a new study that examined eye scans from more than 90,000 people, including a group of over 39,000 who were followed for roughly a decade.
That heart condition, the most common form of irregular heartbeat, is notoriously hard to catch because it often comes and goes without warning, sometimes without any symptoms at all. That gap matters because atrial fibrillation raises the risk of stroke, heart failure and death. This new research suggests a simple eye scan, the kind already done in routine eye checkups, might flag the danger before a doctor ever suspects a heart problem.
Researchers analyzing those eye images found that people with atrial fibrillation had measurably thinner layers in the back of the eye, called the retina, compared with people who didn’t have the condition. The thinning showed up specifically in a layer made of nerve cells called the ganglion cell-inner plexiform layer, and it appeared consistently across both groups studied.
This isn’t the first time scientists have looked at the eye as a window into the rest of the body. The retina shares blood vessels and nerve tissue with the brain and heart, so changes on a scan can reflect problems elsewhere. This study stands out simply for its size, drawing on eye scans from tens of thousands of people rather than a small trial.
Two Large Patient Groups Link Retinal Thinning To Atrial Fibrillation
Scientists pulled data from two very different sources. The first, AlzEye, included more than 50,000 patients age 40 and older who visited a London eye hospital between 2008 and 2018; about 11% had atrial fibrillation. The second, UK Biobank, is a long-running health study that recruited people ages 40 to 69 between 2006 and 2010 and tracked their health over time.
For both groups, researchers used two kinds of eye imaging already common in eye care: color photographs of the retina and optical coherence tomography, a scanning technique that produces detailed cross-section images of the retina’s layers, somewhat like an ultrasound for the eye. From these images, the team measured retinal layer thickness and features of the retina’s tiny blood vessels.
Atrial fibrillation status came from hospital records and, in UK Biobank, self-reported diagnoses. Statisticians then compared retinal measurements between people with and without the condition, adjusting for age, sex, ethnicity, blood pressure and diabetes so those factors wouldn’t skew results. The findings were published in the journal PLOS Digital Health.
One Retinal Layer Consistently Thinner In Atrial Fibrillation Patients
In the hospital-based group, people with atrial fibrillation had thinner retinas across several layers, including nerve fibers that carry visual signals to the brain. But only thinning in that same nerve cell layer also turned up in the UK Biobank group, making it the sole retinal change confirmed across both populations. People with the heart condition also had smaller retinal veins and altered blood vessel branching, though that vascular pattern showed up only in the hospital-based group.
To put the thinning in perspective, researchers noted that the difference seen in the hospital group was roughly equivalent to about 13 years of typical age-related thinning, and about four times the thinning normally associated with daily alcohol drinking. In the UK Biobank group, the difference was comparable to roughly eight years of aging.
Following people over time produced the most compelling evidence. Researchers tracked more than 39,000 UK Biobank participants free of atrial fibrillation at baseline for about 10 years; 838 developed the condition, typically about four years after their initial eye scan. After accounting for other health and lifestyle factors, each standard step of thinning in that nerve cell layer was tied to a 27% higher risk of a later diagnosis. That timing detail matters: the retinal changes were already detectable before atrial fibrillation was formally diagnosed.
Source : https://studyfinds.com/retinal-scan-flags-irregular-heartbeat-risk/