Two Studies Find Gut Fungi Drive Childhood Allergy Risk, With Mouse Research Pointing to Infant Antibiotics as a Culprit
Hundreds of millions of children worldwide live with allergic diseases, and the number keeps climbing. Scientists have spent decades studying the bacterial side of the gut microbiome for clues about why, but two studies published together in Nature Communications point toward a part of that ecosystem that has been almost entirely overlooked: the fungi.
Conducted by separate teams at the University of Calgary and BC Children’s Hospital, both studies converged on the same yeast, called Malassezia, from two very different directions. One team tracked gut fungal development in more than 1,400 Canadian infants and found that babies whose fungal communities matured slowly were more likely to develop atopic dermatitis and food allergy by age five. The other found that infant antibiotics triggered a surge of that same yeast and showed, in mouse models, that it drove immune changes tied to asthma-like airway inflammation. Neither team knew the other had been working on the same fungus until they compared notes.
“Hundreds of millions of children worldwide are affected by allergic diseases, and the number is growing,” said Dr. Stuart Turvey, senior author of the cohort study and a professor of pediatrics at the University of British Columbia. “A better understanding of what gives rise to these conditions and how we can prevent them would have an enormous benefit for children around the globe.”
A Gut Fungus That Tracks With Allergic Disease Risk
Turvey’s team analyzed stool samples from 1,409 participants in the CHILD Cohort Study, a large Canadian birth cohort that follows children from pregnancy through early childhood. By generating fungal sequencing data from 2,256 samples collected at around three months and one year of age, the researchers were able to map how the gut’s fungal community changes during the first year of life.
One pattern stood out immediately. Malassezia was abundant early on and then declined sharply over the first year, while a group of yeasts called Saccharomycetaceae followed the opposite trajectory, increasing steadily with age. Babies whose fungal communities hadn’t followed that expected developmental arc at twelve months, showing a pattern more typical of younger infants, were significantly more likely to be diagnosed with atopic dermatitis or food allergy by the time they turned five. Malassezia was the single strongest fungal predictor of where a baby’s gut microbiome stood developmentally.
Antibiotics, Fungi, and the Immune System
Led by Dr. Marie-Claire Arrieta at the University of Calgary, a second team approached the same fungus from a different angle. Working with 47 infants under six months old who came to Alberta Children’s Hospital’s emergency department needing injectable antibiotics, researchers collected stool samples before and after treatment to analyze bacterial and fungal gut communities.
Antibiotics knocked back bacterial diversity, as expected, but had the opposite effect on fungi. Fungal diversity increased in roughly 79% of the short-term treatment group. One genus expanded more than any other: Malassezia. The single factor most strongly associated with that expansion, even after accounting for birth weight and gestational age, was the total number of different antibiotics a baby received.
To test what that surge could mean for a developing immune system, the team raised mice under sterile conditions and introduced a controlled bacterial community with or without M. restricta, the Malassezia species that had expanded most in the infants. At just three weeks old, the fungus-colonized mice showed a markedly different immune profile, with higher numbers of cells tied to allergic disease and asthma risk, changes that extended beyond the gut into the lymph nodes. When those mice were later exposed to house dust mite, a common asthma trigger, they developed significantly worse airway inflammation. Mice that also had an early RSV infection showed even greater susceptibility to allergic airway inflammation later in life.
“Antibiotics are an essential treatment for young children when needed, but this study shows that there is a previously overlooked effect on the gut mycobiome, allowing species like Malassezia to flourish, and directly impacting immunological function,” said Dr. Arrieta.
Source : https://studyfinds.com/gut-fungus-driving-childhood-allergies-antibiotics/
